Chronic pain and inflammation can really take a toll on your physical and mental health. Oral nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Motrin®, Advil®) can help reduce pain and inflammation. But they also carry certain risks for cardiovascular and kidney issues, stroke, bleeding and ulcers when you take them for extended periods of time. Fortunately, there are topical anti-inflammatory creams that offer the same amount of relief with significantly reduced risks.